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dc.contributor.advisorSantos, Joao Henrique Zimnoch dospt_BR
dc.contributor.authorCorrêa, Gabriel Gironpt_BR
dc.date.accessioned2017-02-21T02:26:14Zpt_BR
dc.date.issued2013pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/152778pt_BR
dc.description.abstractThe effects of sol-gel processes, i.e., acid-catalyzed gelation, base-catalyzed 37 gelation and base-catalyzed precipitation routes, on the encapsulation of 38 gentamicin were investigated. The resulting xerogels were characterized using 39 a series of complementary instrumental techniques, i.e., the 40 adsorption/desorption of nitrogen, small-angle X-ray scattering, Fourier 41 transform infrared spectroscopy, diffuse reflectance spectroscopy, X-ray 42 photoelectron spectroscopy, atomic force microscopy and scanning electron 43 microscopy. The encapsulated gentamicin samples were tested against five 44 bacterial strains, including two Gram-positive (Staphylococcus aureus ATCC 45 25923, Bacillus cereus ATCC 11778) and three Gram-negative strains 46 (Escherichia coli ATCC 25922, Enterobacter aerogenes ATCC 13048 and 47 Salmonella typhimurium ATCC 14028). The best antimicrobial activity was 48 observed for the encapsulated gentamicin that was prepared via the 49 precipitation route, even in comparison with the neat antibiotic, especially in the 50 case of the Gram-positive strain Staphylococcus aureus. The gentamicin 51 concentration on the outermost surface and the zeta potential were identified as 52 factors that affected the highest efficiency, as observed in the case of 53 encapsulation via the base-catalyzed precipitation process.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.rightsOpen Accessen
dc.subjectSol-gelpt_BR
dc.subjectSol-gelen
dc.subjectSilicaen
dc.subjectGentamicinapt_BR
dc.subjectGentamicinen
dc.subjectAtividade antimicrobianapt_BR
dc.subjectAntibacterial activityen
dc.subjectEncapsulaçãopt_BR
dc.subjectEncapsulationen
dc.titleEffects of the sol-gel route on the structural characteristics and antibacterial activity of silica-encapsulated gentamicinpt_BR
dc.typeTrabalho de conclusão de graduaçãopt_BR
dc.identifier.nrb000904996pt_BR
dc.degree.grantorUniversidade Federal do Rio Grande do Sulpt_BR
dc.degree.departmentFaculdade de Farmáciapt_BR
dc.degree.localPorto Alegre, BR-RSpt_BR
dc.degree.date2013pt_BR
dc.degree.graduationFarmáciapt_BR
dc.degree.levelgraduaçãopt_BR


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