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dc.contributor.authorLawisch, Gabriela Kniphoff da Silvapt_BR
dc.contributor.authorGuimarães, Rafaelpt_BR
dc.contributor.authorMattevi, Vanessa Sunept_BR
dc.contributor.authorLazzaretti, Rosmeri Kuhmmerpt_BR
dc.contributor.authorSprinz, Eduardopt_BR
dc.contributor.authorKuhmmer, Reginapt_BR
dc.contributor.authorBrandão, Lucaspt_BR
dc.contributor.authorCrovella, Sérgiopt_BR
dc.contributor.authorChies, Jose Artur Bogopt_BR
dc.date.accessioned2016-12-15T02:15:01Zpt_BR
dc.date.issued2011pt_BR
dc.identifier.issn1473-5571pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/150073pt_BR
dc.description.abstractObjective: This study investigates the role of mannose-binding lectin (MBL) in the susceptibility to HIV-1 infection analyzing polymorphisms located at the MBL2 promoter and exon 1 regions. Materials and methods: The prevalence of MBL2 variant alleles was investigated in 410 HIV-1-infected patients from the South Brazilian HIV cohort and in 345 unexposed uninfected healthy individuals. The promoter variants were genotyped using polymerase chain reaction with sequence-specific primers (PCR-SSP) and exon 1 variants were analyzed by real-time PCR using a melting temperature assay and were confirmed by PCR-restriction fragment length polymorphism (RFLP). MBL2 genotypic and allelic frequencies were compared between HIV-1-infected patients and controls using the chi-squared tests. Results: The analyses were performed subdividing the individuals according to their ethnic origin. Among Euro-derived individuals a higher frequency of the LX/LX genotype was observed in patients when compared to controls (P<0.001). The haplotypic analysis also showed a higher frequency of the haplotypes associated with lower MBL levels among HIV-1-infected patients (P¼0.0001). Among Afro-derived individuals the frequencies of LY/LY and HY/HY genotypes were higher in patients when compared to controls (P¼0.009 and P¼0.02). Conclusions: An increased frequency of MBL2 genotypes associated with low MBL levels was observed in Euro-derived patients, suggesting a potential role for MBL in the susceptibility to HIV-1 infection in Euro-derived individuals.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofAIDS. London. Vol. 25, no. 4 (Feb. 2011), p. 411–418pt_BR
dc.rightsOpen Accessen
dc.subjectSíndrome da imunodeficiência adquiridapt_BR
dc.subjectEthnicityen
dc.subjectPolimorfismo genéticopt_BR
dc.subjectHIVen
dc.subjectImmunogeneticsen
dc.subjectHIV-1pt_BR
dc.subjectBrasilpt_BR
dc.subjectMBLen
dc.subjectPolymorphismsen
dc.titleThe role of mannose-binding lectin gene polymorphisms in susceptibility to HIV-1 infection in Southern Brazilian patientspt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb000783659pt_BR
dc.type.originEstrangeiropt_BR


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