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dc.contributor.authorMoehlecke, Milenept_BR
dc.contributor.authorCanani, Luis Henrique Santospt_BR
dc.contributor.authorSilva, Lucas Oliveira Junqueira ept_BR
dc.contributor.authorTrindade, Manoel Roberto Macielpt_BR
dc.contributor.authorFriedman, Rogériopt_BR
dc.contributor.authorLeitão, Cristiane Bauermannpt_BR
dc.date.accessioned2016-08-24T02:15:56Zpt_BR
dc.date.issued2016pt_BR
dc.identifier.issn2359-4292pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/147576pt_BR
dc.description.abstractBody weight is regulated by the ability of hypothalamic neurons to orchestrate behavioral, endocrine and autonomic responses via afferent and efferent pathways to the brainstem and the periphery. Weight maintenance requires a balance between energy intake and energy expenditure. Although several components that participate in energy homeostasis have been identified, there is a need to know in more detail their actions as well as their interactions with environmental and psychosocial factors in the development of human obesity. In this review, we examine the role of systemic mediators such as leptin, ghrelin and insulin, which act in the central nervous system by activating or inhibiting neuropeptide Y, Agouti-related peptide protein, melanocortin, transcript related to cocaine and amphetamine, and others. As a result, modifications in energy homeostasis occur through regulation of appetite and energy expenditure. We also examine compensatory changes in the circulating levels of several peripheral hormones after diet-induced weight loss.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofArchives of endocrinology and metabolism. São Paulo. Vol. 60, no. 2 (Apr. 2016), p. 152-162.pt_BR
dc.rightsOpen Accessen
dc.subjectRegulação do apetitept_BR
dc.subjectAppetite regulationen
dc.subjectEnergy metabolismen
dc.subjectMetabolismo energéticopt_BR
dc.subjectPeso corporalpt_BR
dc.subjectEnergy expenditureen
dc.subjectBody weighten
dc.titleDeterminants of body weight regulation in humanspt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb000998476pt_BR
dc.type.originNacionalpt_BR


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