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dc.contributor.authorBellagamba, Bruno Corrêapt_BR
dc.contributor.authorAbreu, Bianca Regina Ribas dept_BR
dc.contributor.authorGrivicich, Ivanapt_BR
dc.contributor.authorMarkarian, Carolina Frankept_BR
dc.contributor.authorChem, Eduardo Mainieript_BR
dc.contributor.authorCamassola, Melissapt_BR
dc.contributor.authorNardi, Nance Beyerpt_BR
dc.contributor.authorDihl, Rafael Rodriguespt_BR
dc.date.accessioned2016-08-16T02:15:11Zpt_BR
dc.date.issued2016pt_BR
dc.identifier.issn1415-4757pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/147212pt_BR
dc.description.abstractMesenchymal stem cells (MSCs) are known for their important properties involving multilineage differentiation potential, trophic factor secretion and localization along various organs and tissues. On the dark side, MSCs play a distinguished role in tumor microenvironments by differentiating into tumor-associated fibroblasts or supporting tumor growth via distinct mechanisms. Cisplatin (CIS) is a drug widely applied in the treatment of a large number of cancers and is known for its cytotoxic and genotoxic effects, both in vitro and in vivo. Here we assessed the effects of CIS on MSCs and the ovarian cancer cell line OVCAR-3, by MTT and comet assays. Our results demonstrated the resistance of MSCs to cell death and DNA damage induction by CIS, which was not observed when OVCAR-3 cells were exposed to this drug.en
dc.format.mimetypeapplication/pdf
dc.language.isoengpt_BR
dc.relation.ispartofGenetics and molecular biology. Ribeirão Preto, SP. Vol. 39, no. 1 (Jan./Mar. 2016), p. 129-134pt_BR
dc.rightsOpen Accessen
dc.subjectMesenchymal stem cellsen
dc.subjectCisplatinapt_BR
dc.subjectCisplatinen
dc.subjectCitotoxicidadept_BR
dc.subjectGenotoxicidadept_BR
dc.subjectMTTen
dc.subjectComet assayen
dc.subjectOVCAR-3 cellsen
dc.titleHuman mesenchymal stem cells are resistant to cytotoxic and genotoxic effects of cisplatin in vitropt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb000992330pt_BR
dc.type.originNacionalpt_BR


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