The lactase persistence genotype is a protective factor for the metabolic syndrome
dc.contributor.author | Friedrich, Denise Barbosa de Castro | pt_BR |
dc.contributor.author | Andrade, Fabiana Michelsen de | pt_BR |
dc.contributor.author | Fiegenbaum, Marilu | pt_BR |
dc.contributor.author | Almeida, Silvana de | pt_BR |
dc.contributor.author | Mattevi, Vanessa Sune | pt_BR |
dc.contributor.author | Callegari-Jacques, Sidia Maria | pt_BR |
dc.contributor.author | Hutz, Mara Helena | pt_BR |
dc.date.accessioned | 2015-07-07T02:01:26Z | pt_BR |
dc.date.issued | 2014 | pt_BR |
dc.identifier.issn | 1415-4757 | pt_BR |
dc.identifier.uri | http://hdl.handle.net/10183/118590 | pt_BR |
dc.description.abstract | The Metabolic Syndrome (MetS) is defined as a pattern of metabolic disturbances, which include central obesity, insulin resistance and hyperglycemia, dyslipidemia, and hypertension. Milk has been promoted as a healthy beverage that can improve the management of MetS. Most human adults, however, down-regulate the production of intestinal lactase after weaning. Lactase encoded by the LCT gene is necessary for lactose digestion. The -13910C > T SNP (rs4988235) is responsible for the lactase persistence phenotype in European populations. We herein investigated whether the lactase persistence genotype is also associated with the MetS in subjects from a Brazilian population of European descent. This study consisted of 334 individuals (average age of 41 years) genotyped by PCR-based methods for the -13910C > T SNP. Clinical data were assessed and the genotypes were tested for their independent contribution to the MetS using chi-square tests and multiple logistic regression analysis. Univariate analyses showed that hypertension and MetS prevalence were higher in individuals with the lactase non-persistence genotype than in lactase persistence subjects. Furthermore, lactase persistence was associated with a lower risk for MetS (OR = 0.467; 95% CI 0.264-0.824; p = 0.009). These results suggest that LCT genotypes can be a valuable tool for the management of MetS treatment. | en |
dc.format.mimetype | application/pdf | |
dc.language.iso | eng | pt_BR |
dc.relation.ispartof | Genetics and molecular biology. Ribeirão Preto. Vol. 37, no. 4 (2014), p. 611-615 | pt_BR |
dc.rights | Open Access | en |
dc.subject | Metabolic syndrome | en |
dc.subject | Estatística aplicada | pt_BR |
dc.subject | Lactase persistence | en |
dc.subject | Hypolactasia | en |
dc.subject | Lactose | en |
dc.title | The lactase persistence genotype is a protective factor for the metabolic syndrome | pt_BR |
dc.type | Artigo de periódico | pt_BR |
dc.identifier.nrb | 000952279 | pt_BR |
dc.type.origin | Nacional | pt_BR |
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