Mostrar registro simples

dc.contributor.authorTrentin, Danielle da Silvapt_BR
dc.contributor.authorSilva, Denise Brentanpt_BR
dc.contributor.authorFrasson, Amanda Piccolipt_BR
dc.contributor.authorRzhepishevska, Olenapt_BR
dc.contributor.authorSilva, Márcia Vanusa dapt_BR
dc.contributor.authorPulcini, Elinor de L.pt_BR
dc.contributor.authorJames, Garthpt_BR
dc.contributor.authorSoares, Gabriel Vieirapt_BR
dc.contributor.authorTasca, Tianapt_BR
dc.contributor.authorRamstedt, Madeleinept_BR
dc.contributor.authorGiordani, Raquel Brandtpt_BR
dc.contributor.authorLopes, Norberto Peporinept_BR
dc.contributor.authorMacedo, Alexandre Josépt_BR
dc.date.accessioned2015-03-26T01:58:33Zpt_BR
dc.date.issued2015pt_BR
dc.identifier.issn2045-2322pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/114534pt_BR
dc.description.abstractDespite many advances, biomaterial-associated infections continue to be a major clinical problem. In order to minimize bacterial adhesion, material surface modifications are currently being investigated and natural products possess large potential for the design of innovative surface coatings. We report the bioguided phytochemical investigation of Pityrocarpa moniliformis and the characterization of tannins by mass spectrometry. It was demonstrated that B-type linked proanthocyanidins-coated surfaces, here termed Green coatings, reduced Gram-positive bacterial adhesion and supported mammalian cell spreading. The proposed mechanism of bacterial attachment inhibition is based on electrostatic repulsion, high hydrophilicity and the steric hindrance provided by the coating that blocks bacterium-substratum interactions. This work shows the applicability of a prototype Green-coated surface that aims to promote necessary mammalian tissue compatibility, while reducing bacterial colonization.en
dc.format.mimetypeapplication/pdf
dc.language.isoengpt_BR
dc.relation.ispartofScientific reports. London. Vol. 5 (Feb. 2015), 8287, 10 p.pt_BR
dc.rightsOpen Accessen
dc.subjectBiofilmespt_BR
dc.subjectMicrobiologiapt_BR
dc.subjectEspectrometria de massapt_BR
dc.titleNatural green coating inhibits adhesion of clinically important bacteriapt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb000955574pt_BR
dc.type.originEstrangeiropt_BR


Thumbnail
   

Este item está licenciado na Creative Commons License

Mostrar registro simples