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dc.contributor.authorVargas, Carla Vaz Ferreirapt_BR
dc.contributor.authorSiqueira, Débora Rodriguespt_BR
dc.contributor.authorCeolin, Lucielipt_BR
dc.contributor.authorMaia, Ana Luiza Silvapt_BR
dc.date.accessioned2015-03-04T01:58:09Zpt_BR
dc.date.issued2013pt_BR
dc.identifier.issn1179-1322pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/111628pt_BR
dc.description.abstractMedullary thyroid carcinoma (MTC) is a rare malignant tumor originating from thyroid parafollicular C cells. This tumor accounts for 3%–4% of thyroid gland neoplasias. MTC may occur sporadically or be inherited. Hereditary MTC appears as part of the multiple endocrine neoplasia syndrome type 2A or 2B, or familial medullary thyroid cancer. Germ-line mutations of the RET proto-oncogene cause hereditary forms of cancer, whereas somatic mutations can be present in sporadic forms of the disease. The RET gene encodes a receptor tyrosine kinase involved in the activation of intracellular signaling pathways leading to proliferation, growth, differentiation, migration, and survival. Nowadays, early diagnosis of MTC followed by total thyroidectomy offers the only possibility of cure. Based on the knowledge of the pathogenic mechanisms of MTC, new drugs have been developed in an attempt to control metastatic disease. Of these, small-molecule tyrosine kinase inhibitors represent one of the most promising agents for MTC treatment, and clinical trials have shown encouraging results. Hopefully, the cumulative knowledge about the targets of action of these drugs and about the tyrosine kinase inhibitor-associated side effects will help in choosing the best therapeutic approach to enhance their benefits.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofCancer management and research. [Auckland, N.Z.]. Vol. 5 (2013), p. 57-66pt_BR
dc.rightsOpen Accessen
dc.subjectMedullary thyroid carcinomaen
dc.subjectCarcinoma medularpt_BR
dc.subjectGlândula tireóidept_BR
dc.subjectProto-oncogene RETen
dc.subjectProteínas proto-oncogênicas c-retpt_BR
dc.subjectTyrosine kinase inhibitorsen
dc.subjectProteínas tirosina quinasespt_BR
dc.titleAdvanced medullary thyroid cancer : pathophysiology and managementpt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb000942109pt_BR
dc.type.originEstrangeiropt_BR


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