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dc.contributor.authorDellaméa, Bruno Schmidtpt_BR
dc.contributor.authorLeitão, Cristiane Bauermannpt_BR
dc.contributor.authorFriedman, Rogériopt_BR
dc.contributor.authorCanani, Luis Henrique Santospt_BR
dc.date.accessioned2015-02-21T01:57:00Zpt_BR
dc.date.issued2014pt_BR
dc.identifier.issn1758-5996pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/110276pt_BR
dc.description.abstractAbout 30% of patients with type 2 diabetes mellitus develop clinically overt nephropathy. Hyperglycemia is necessary, but not sufficient, to cause the renal damage that leads to kidney failure. Diabetic nephropathy (DN) is a multifactorial disorder that results from interaction between environmental and genetic factors. In the present article we will review the role of the nitric oxide synthase (NOS) in the pathogenesis of DN. Nitric oxide (NO) is a short-lived gaseous lipophilic molecule produced in almost all tissues, and it has three distinct genes that encode three NOS isoforms: neuronal (nNOS), inducible (iNOS) and endothelial (eNOS). The correct function of the endothelium depends on NO, participating in hemostasis control, vascular tone regulation, proliferation of vascular smooth muscle cells and blood pressure homeostasis, among other features. In the kidney, NO plays many different roles, including control of renal and glomerular hemodynamics. The net effect of NO in the kidney is to promote natriuresis and diuresis, along with renal adaptation to dietary salt intake. The eNOS gene has been considered a potential candidate gene for DN susceptibility. Three polymorphisms have been extensively researched: G894T missense mutation (rs1799983), a 27-bp repeat in intron 4, and the T786C single nucleotide polymorphism (SNP) in the promoter (rs2070744). However, the potential link between eNOS gene variants and the induction and progression of DN yielded contradictory results in the literature. In conclusion, NOS seems to be involve in the development and progression of DN. Despite the discrepant results of many studies, the eNOS gene is also a good candidate gene for DN.en
dc.format.mimetypeapplication/pdf
dc.language.isoengpt_BR
dc.relation.ispartofDiabetology & metabolic syndrome. [London]. Vol. 6 (Feb. 2014), p. 17pt_BR
dc.rightsOpen Accessen
dc.subjectDiabetesen
dc.subjectNefropatias diabéticaspt_BR
dc.subjectDiabetic nephropathyen
dc.subjectPolimorfismo genéticopt_BR
dc.subjectDiabetes mellitus tipo 2pt_BR
dc.subjectPolymorphismen
dc.subjectÓxido nítricopt_BR
dc.subjecteNOSen
dc.subjectNOS-3en
dc.subjectG894Ten
dc.subject4b/aen
dc.subjectT786Cen
dc.titleNitric oxide system and diabetic nephropathypt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb000945097pt_BR
dc.type.originEstrangeiropt_BR


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