Show simple item record

dc.contributor.authorPicon, Paulo Dornellespt_BR
dc.contributor.authorPicon, Rafael da Veiga Chavespt_BR
dc.contributor.authorCosta, Andry Fitermanpt_BR
dc.contributor.authorSander, Guilherme Beckerpt_BR
dc.contributor.authorAmaral, Karine Medeirospt_BR
dc.contributor.authorAboy, Ana Lúciapt_BR
dc.contributor.authorHenriques, Amelia Teresinhapt_BR
dc.date.accessioned2015-02-11T02:18:15Zpt_BR
dc.date.issued2010pt_BR
dc.identifier.issn1472-6882pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/109974pt_BR
dc.description.abstractBackground: A phytotherapic compound containing Pimpinella anisum L., Foeniculum vulgare Miller, Sambucus nigra L., and Cassia augustifolia is largely used in Brazil for the treatment of constipation. However, the laxative efficacy of the compound has never been tested in a randomized clinical trial. The aim of this study was to evaluate the efficacy and safety of the product. Methods: This randomized, crossover, placebo-controlled, single-blinded trial included 20 patients presenting with chronic constipation according to the criteria of the American Association of Gastroenterology. The order of treatments was counterbalanced across subjects: half of the subjects received the phytotherapic compound for a 5-day period, whereas the other half received placebo for the same period. Both treatment periods were separated by a 9-day washout period followed by the reverse treatment for another 5-day period. The primary endpoint was colonic transit time (CTT), measured radiologically. Secondary endpoints included number of evacuations per day, perception of bowel function, adverse effects, and quality of life. Results: Mean CTT assessed by X ray was 15.7 hours (95%CI 11.1-20.2) in the active treatment period and 42.3 hours (95%CI 33.5-51.1) during the placebo treatment (p < 0.001). Number of evacuations per day increased during the use of active tea; significant differences were observed as of the second day of treatment (p < 0.001). Patient perception of bowel function was improved (p < 0.01), but quality of life did not show significant differences among the study periods. Except for a small reduction in serum potassium levels during the active treatment, no significant differences were observed in terms of adverse effects throughout the study period. Conclusions: The findings of this randomized controlled trial allow to conclude that the phytotherapic compound assessed has laxative efficacy and is a safe alternative option for the treatment of constipation. Trial registration: ClinicalTrial.gov NCT00872430en
dc.format.mimetypeapplication/pdf
dc.language.isoporpt_BR
dc.relation.ispartofBMC Complementary and Alternative Medicine. London. Vol. 10, no. 17 (2010), 9 p.pt_BR
dc.rightsOpen Accessen
dc.subjectFitoterapiapt_BR
dc.subjectPimpinellapt_BR
dc.subjectFoeniculum sativumpt_BR
dc.subjectSambucus nigrapt_BR
dc.subjectCinnamomum aromaticumpt_BR
dc.subjectConstipação intestinalpt_BR
dc.subjectEficáciapt_BR
dc.titleRandomized clinical trial of a phytotherapic compound containing Pimpinella anisum, Foeniculum vulgare, Sambucus nigra, and Cassia augustifolia for chronic constipationpt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb000772274pt_BR
dc.type.originEstrangeiropt_BR


Files in this item

Thumbnail
   

This item is licensed under a Creative Commons License

Show simple item record