MSX1 and PAX9 investigation in monozygotic twins with variable expression of tooth agenesis
Fecha
2013Autor
Materia
Abstract
Non-syndromic agenesis of permanent teeth is one of the most common anomalies in human development, a multifactorial characteristic caused by genetic and environmental factors. We describe a pair of monozygotic twins who showed second premolar and third molar agenesis, albeit with different expressions. We studied the DNA of two genes, paired domain box gene 9 (PAX9) and muscle segment homeodomain-homeobox1 (MSX1), encoding transcription factors that earlier studies found were involved in the m ...
Non-syndromic agenesis of permanent teeth is one of the most common anomalies in human development, a multifactorial characteristic caused by genetic and environmental factors. We describe a pair of monozygotic twins who showed second premolar and third molar agenesis, albeit with different expressions. We studied the DNA of two genes, paired domain box gene 9 (PAX9) and muscle segment homeodomain-homeobox1 (MSX1), encoding transcription factors that earlier studies found were involved in the manifestation of this condition. No specific causative mutation was found. However, we detected a C→T change in MSX1 exon 2 in both twins, suggesting that this polymorphism might be involved in the trait’s expression. ...
En
Twin Research and Human Genetics. Cambridge, England. Vol. 16, no. 6 (Dec. 2013), p. 1112-1116
Origen
Estranjero
Colecciones
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Artículos de Periódicos (39774)Ciencias de la Salud (10633)
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Artículos de Periódicos (39774)Ciencias Biologicas (3109)
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