Browsing by Subject "Next-generation sequencing"
Now showing items 1-12 of 12
-
Analysis of the transcriptional and translational profile of agrp neurons
(2019) [Work completion of graduation]Agrp neurons are a small population of neurons in the arcuate nucleus of the hypothalamus known to drive feeding behavior. They are sensitive to hormones such as leptin, ghrelin, and insulin, and play a central role in the ... -
Avaliação dos mecanismos adquiridos de resistência a antimicrobianos em enterobactérias produtoras de carbapenemases por sequenciamento de nova geração
(2016) [Dissertation]O objetivo deste trabalho foi caracterizar os mecanismos adquiridos de resistência de isolados de enterobactérias produtoras de carbapenemases utilizando a tecnologia de sequenciamento de nova geração. Foram incluídos no ... -
Caracterização genômica de isolados de Staphylococcus pseudintermedius provenientes de infecção canina
(2024) [Dissertation]Staphylococcus pseudintermedius é uma bactéria de significativa importância clínica em infecções caninas, frequentemente associada a uma variedade de enfermidades cutâneas e sistêmicas em cães. Embora seja normalmente um ... -
Comparative analysis of the upper respiratory bacterial communities of pigs with or without respiratory clinical signs : from weaning to finishing phase
(2022) [Journal article]A prospective study was conducted to identify bacterial communities in the nasal and laryngeal cavities of pigs with or without clinical signs of respiratory disease in a longitudinal fashion, from weaning to the finishing ... -
Complete sequence and comparative analysis of the chloroplast genome of Plinia trunciflora
(2017) [Journal article]Plinia trunciflora is a Brazilian native fruit tree from the Myrtaceae family, also known as jaboticaba. This species has great potential by its fruit production. Due to the high content of essential oils in their leaves ... -
Defining microbial biomarkers for risk of preterm labor
(2020) [Journal article]Preterm birth remains the main contributor to early childhood mortality. The vaginal environment, including microbiota com-position, might contribute to the risk of preterm delivery. Alterations in the vaginal microbial ... -
Detection of mosaic variants in mothers of MPS II patients by next generation sequencing
(2021) [Journal article]Mucopolysaccharidosis type II is an X-linked lysosomal storage disorder caused by mutations in the IDS gene that encodes the iduronate-2-sulfatase enzyme. The IDS gene is located on the long arm of the X-chromosome, ... -
Development of microsatellite markers for use in breeding catfish, Rhamdia sp
(2015) [Journal article]Microsatellites markers for catfish, Rhamdia sp. were developed using Next Generation. A shotgun paired-end library was prepared according to standard protocol of Illumina Nextera DNA Library Kit with dual indexing, ... -
Diagnóstico molecular das neuropatias hereditárias : doença de Charcot-Marie-Tooth e neuropatia hereditária com suscetibilidade à paralisia por pressão
(2020) [Dissertation]Base teórica: As neuropatias hereditárias, em especial a doença de Charcot-Marie-Tooth (CMT), são um grupo de doenças com grande heterogeneidade genética, havendo mais de 60 genes associados a estas condições. Diversos ... -
Sensitivity, advantages, limitations, and clinical utility of targeted next-generation sequencing panels for the diagnosis of selected lysosomal storage disorders
(2019) [Journal article]Lysosomal storage disorders (LSDs) constitute a heterogeneous group of approximately 50 genetic disorders. LSDs diagnosis is challenging due to variability in phenotype penetrance, similar clinical manifestations, and a ... -
Sequenciamento de última geração aplicado à virologia veterinária
(2015) [Work completion of graduation]Os vírus são microrganismos que ocorrem em todos os seres vivos e possuem altas taxas de mutação, sendo assim, necessitam de técnicas adequadas para sua detecção. A metagenômica viral permite a investigação da flora viral ... -
Variantes germinativas no gene POLQ em pacientes com câncer de mama bilateral
(2017) [Dissertation]Pacientes com síndromes hereditárias de predisposição ao câncer podem ser portadores de mutações em genes associados ao reparo de quebras bifilamentares de DNA (DSB). Uma alta expressão da polimerase theta (Pol Θ), uma ...
