Browsing by Subject "Gene rearrangements"

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    • BRCA1 and BRCA2 rearrahgements in brazilian individuals with hereditary breast and ovarian cancer syndrome 

      Ewald, Ingrid Petroni; Cossio, Silvia Liliana; Palmero, Edenir Inêz; Pinheiro, Manuela; Nascimento, Ivana Lucia de Oliveira; Machado, Taisa Manuela Bonfim; Sandes, Kiyoko Abé; Toralles, Betânia; Garicochea, Bernardo; Ribeiro, Patrícia Lisbôa Izetti; Pereira, Maria Luiza Saraiva; Bock, Hugo; Vargas, Fernando Regla; Moreira, Miguel Angelo Martins; Peixoto, Ana; Teixeira, Manuel R.; Prolla, Patrícia Ashton (2016) [Journal article]
      Approximately 5-10% of breast cancers are caused by germline mutations in high penetrance predisposition genes. Among these, BRCA1 and BRCA2, which are associated with the Hereditary Breast and Ovarian Cancer (HBOC) syndrome, ...